Contents: (Adv. Sci. 11/2016)

In article 1600229, Shilong Wang, Rongrong Zhu, Yechang Qian, and co-workers investigate the anti-metastatic and anti-angiogenic effects of SiO2@LDH (LDH: layered double hydroxide) loaded with etoposide (VP16). SiO2@LDH has very suitable qualities as drug delivery agent and enhances the anti-metastatic action of VP16 both in vitro and in vivo. Enhanced anti-angiogenic efficacy is also proven which might contribute to the anti-cancer action. The cover image represents the 3D structure of core-shell SiO2@ LDH-VP16, which silicon dioxide sphere flexibly enclosed by double-layered hydroxide.